Dr. Uwe Rohr

A Researcher in Phytoestrogens and Steroid Hormones

This website is dedicated to the late Dr. Uwe Rohr, a German pharmacist and medical scientist who did outstanding research in the effects of phytoestrogens, most notably soy isoflavones (daidzein and genistein), on the human organism. He investigated why these natural compounds have such a positive effect on the treatment of severe mental diseases, infectious diseases, cancer and wounds, and hypothesized that they acted by influencing the steroid hormone cascade, converting stress hormones into immunity hormones.

Biographical Sketch

The son of working-class parents, Uwe Rohr (born in 1956) was the first in his family to graduate from high school. He first studied pharmacy and obtained his PhD and Habilitation degrees at the University of Bonn. In the years 1982 to 1989, Uwe Rohr was a professor at the University of Utah, Salt Lake City. Thereupon he studied medicine and had a clinical training in gynecology at the University of Essen under the supervision of Adolf Eduard Schindler, followed by seven years of training in internal medicine under the supervision of Katrin Saeger Lorenz. Since 2002 he was living in Vienna where he was working on publications about menopause, cancer and severe mental diseases together with Anca Gabriella Gocan. In 2014 he founded the company Endobal together with a Viennese businessman with the aim being the development of drugs for treatment of brain tumors in children and of severe mental diseases in soldiers. In the last three years of his life, he was mainly working on scientific publications together with Claus Volko. Uwe Rohr passed away in 2016.

Scientific Achievement

Uwe Rohr was interested in the pharmacodynamics of soy isoflavones such as daidzein and genistein. It is commonly accepted by medical scientists that soy isoflavones have similar effects as the adiols (androstanediol and androstenediol), which are steroid hormones that naturally appear in the human organism, including anti-inflammatory and anti-androgenic effects. However, Uwe Rohr was of the opinion that soy isoflavones did not exert this effect directly but rather indirectly by stimulating the conversion of other steroid hormones into adiols. Moreover, he suggested that there are two types of steroid hormones: One type is released as a reaction to stress, boosts physical performance and weakens the immune system. The other type, which the adiols belong to, has exactly the opposite effect. Uwe Rohr believed that by converting what he called stress hormones into immunity hormones, severe mental diseases, infectious diseases and even cancer could be effectively treated.

Support for talented people

Besides to science, one of the topics Uwe Rohr was most interested in was high intellectual ability and how people with such ability were often discriminated against by their less talented counterparts in academia. He sought to actively support young university graduates with high intellectual ability to enable them to make a career that would allow them to make use of their abilities for the benefit of humanity.

Publications

Articles written by Dr. Rohr's intellectual heirs

Claus Volko: Symbiont Conversion Theory (2018)

Claus Volko: The Synthesis of Metaphysics and Jungian Personality Theory (2018)

Claus Volko: Hormones and their effect on stress and the immune system (2013)

Articles authored or co-authored by Dr. Uwe Rohr

Claus Volko, Pedro-Antonio Regidor and Uwe Rohr: Model approach for stress induced steroidal hormone cascade changes in severe mental diseases (2016)

Pedro-Antonio Regidor, Claus Volko and Uwe Rohr: The evolution of genomic stability to a mechanism in reproduction and psychiatry (2016)

Claus Volko and Uwe Rohr: Can Plants' Ability for DNA Repair and Stress Defense be Used against Patients' Circulating Tumor Cells? (2015)

Claus Volko and Uwe Rohr: Die gesellschaftlichen Folgen der Pille. Werden Großmütter die besseren Mütter? (2015)

Uwe Rohr: Höchstbegabtenförderung (2014)

Markus Strasser, Claus Volko and Uwe Rohr: Nachschulische Förderung von Höchstbegabten (2014)

Claus Volko, Uwe Rohr et al.: Paradigmenwechsel in der Krebstherapie. Was lehrt das invasive und außergewöhnlich rasche Wachstum von Trophoblast bzw. Plazenta? (2014)

Uwe Rohr, Claus Volko and Adolf Schindler: Comparison of steady state development and reduction of menopausal symptoms after oral or transdermal delivery of 17-ß-estradiol in young healthy symptomatic menopausal women (2014)

Uwe Rohr et al.: The effect of fermented soy (FSWW08) on blood hematology and cachexia in cancer patients (2012)

Anca Gocan, Uwe Rohr et al.: Balancing steroidal hormone cascade in treatment-resistant veteran soldiers with PTSD using a fermented soy product (FSWW08): A pilot study (2012)

Anca Gocan, Uwe Rohr et al.: Managing immunity in resistant cancer patients correlates to survival: Results and discussion of a pilot study (2011)

Uwe Rohr et al.: Cancer protection of soy resembles cancer protection during pregnancy (2010)

Uwe Rohr et al.: Applikation von fermentierter Soja bei Krebspatienten zur Verminderung von Kachexie und Erhöhung der Apoptose - eine prospektive Pilotstudie (2009)

Uwe Rohr et al.: Application of soy in cancer patients to reduce cachexia and increase apoptosis by fermental soy - A prospective pilot study (2009)

Uwe Rohr et al.: Phytoestrogens from red clover (2005)

Uwe Rohr et al.: The safety of synthetic paclitaxel by intralesional delivery with OncoGeltrade mark into skin breast cancer metastases: method and results of a clinical pilot trial (2005)

Uwe Rohr et al.: Phytoestrogens derived from red clover: An alternative to estrogen replacement therapy? (2005)

Uwe Rohr et al.: Progesterone increase under DHEA-substitution in males (2003)

Uwe Rohr et al.: Hat die Ausprägung, Ausdehnung und Lokalisation der peritonealen Endometriose einen prädiktiven Wert für Schmerzsymptomatik und Sterilität? (2002)

Pedro-Antonio Regidor, Uwe Rohr et al.: Langzeitergebnisse in der Behandlung der Endometriose mit dem GnRH-Agonisten Nafarelinacetat (Synarela®) (2002)

Uwe Rohr: The impact of testosterone imbalance on depression and women's health (2002)

René Druckmann and Uwe Rohr: IGF-1 in gynaecology and obstetrics: Update 2002 (2002)

Uwe Rohr and Jens Herold: Melatonin deficiencies in women (2002)

Uwe Rohr and Katrin Saeger-Lorenz: 17ß-estradiol matrixpatch removal and reapplication in postmenopausal women: Experimental results (2002)

Uwe Rohr and Katrin Saeger-Lorenz: 17ß-estradiol matrixpatch removal and reapplication in postmenopausal women: Theoretical predictions with an oscillating diffusion coefficient model (2002)

Johannes Huber, Uwe Rohr et al.: Europäische Gynäkologen analysieren WHI-Hormonstudie amerikanischer Kardiologen (2002)

Inka Wiegratz, Uwe Rohr et al.: Cross-over comparison of the pharmacokinetics of estradiol during hormone replacement therapy with estradiol valerate or micronized estradiol (2001)

Inka Wiegratz, Uwe Rohr et al.: Überkreuz-Vergleich der Pharmakokinetik von Estradiol unter der Hormonsubstitution mit Estradiolvalerat oder mikronisiertem Estradiol (2001)

Georg Schmittmann and Uwe Rohr: Comparison of the Permeability Surface Product (PS) of the Blood Capillary Wall in Skeletal Muscle Tissue of Various Species and In Vitro Porous Membranes Using Hydrophilic Drugs (2000)

Uwe Rohr et al.: 17ß-Estradiol delivered by three different matrix patches 50 microgram/day - A three way cross-over study in 21 postmenopausal women (1999)

Ralf Altenburger, Uwe Rohr and Thomas Kissel: Rate control in transdermal beta-estradiol reservoir membrane systems: the role of membrane and adhesive layer (1998)

Ralf Altenburger, Uwe Rohr and Thomas Kissel: Rate Control in Transdermal ß-Estradiol Reservoir Membrane Systems: The Role of Membrane and Adhesive Layer (1998)

Uwe Rohr, Ralf Altenburger and Thomas Kissel: Pharmacokinetics of the transdermal reservoir membrane system delivering beta-estradiol: in vitro/in vivo-correlation (1998)

Uwe Rohr, Ralf Altenburger and Thomas Kissel: Pharmacokinetics of the Transdermal Reservoir Membrane System Delivering ß-Estradiol: In Vitro/In Vivo-Correlation (1998)

Uwe Rohr et al.: Plasma profiles of transdermal 17ß-estradiol delivered by two different matrix patches: A four-way cross-over study in postmenopausal women (1997)

Uwe Rohr et al.: P287 - A new second generation transdermal drug delivery system for HRT: Mechanism of action (1996)

Uwe Rohr et al.: Kinetics of a new patch for transdermal administration of 17 beta-estradiol (1995)

Uwe Rohr et al.: Transdermal delivery of the tetrapeptide Hisetal (melanotropin (6-9)) and amino acids: their contribution to the elucidation of the existence of an 'aqueous pore' pathway (1994)

Uwe Rohr et al.: Examination of iontophoretic transport of ionic drugs across skin: Baseline studies with the four-electrode system (1989)

Uwe Rohr et al.: The effects of ethanol on the transport of estradiol and other permeants in hairless mouse skin - A new quantitative approach (1987)

Uwe Rohr et al.: Effects of Ethanol on the Transport of ß-Estradiol in Hairless Mouse Skin (1987)

Uwe Rohr et al.: The development of a rat/human skin flap served by a defined and accessible vasculature on a congenitally athymic (Nude) rat (1986)

Uwe Rohr et al.: The Development of a Rat/Human Skin Flap Served by a Defined and Accessible Vasculature on a Congenitally Athymic (Nude) Rat (1985)

Claus D. Volko, June 26, 2018